马端

学术任职

中华医学会医学遗传学分会副主任委员，中国医师协会医学遗传分会临床遗传学专委会副主任委员，上海市医学会医学遗传学专委会主任委员，上海市医学会罕见病专委会副主任委员，上海市健康科技协会基因健康专委会主任委员。

学术贡献

发表论文200余篇，其中SCI论文100余篇。编撰“临床遗传学”等学术专著五部。获美国发明专利2项，中国发明专利4项。

文献发表

ZhangJ, Du YY, Xu F, Xu C, Wang HJ, Deng SS, Zhang TY, Ma D*. miRNA Deregulation in Right Ventricular Outflow Tract Myocardium of Non-syndromic Tetralogy of Fallot. Canadian Journal of Cardiology. Can J Cardiol. 2013 Dec;29(12):1695-703.

Sheng W, Qian Y, Wang H, Ma X, Zhang P, Chen L, Ma D*, Huang G*. Association between mRNA levels of DNMT1, DNMT3A, DNMT3B, MBD2 and LINE-1 methylation status in infants with tetralogy of Fallot. Int J Mol Med. 2013;32(3):694-702

Zhang YL, Wang LN, Zhou WH, Zhang J, Wang HJ, Jiang Q, Deng SS, Li WH, Wang L, Li HW, Mao ZH, Ma D*. Tissue factor pathway inhibitor-2: A novel gene involved in zebrafish central nervous system development. Developemntal Biology 2013;381(1):38-49.  

Wang T, Qian YY, Hua KQ, Ma D*. The Relationship Between Insulin Resistance and CpG Island Methylation of LMNA Gene in Polycystic Ovary Syndrome. Cell Biochemistry and Biophysics. April 2013

Yao G,Chen D, Wang H, Li S, Zhang J, Feng Z, Guo L, Yang Z, Yang S, Sun C, Zhang X, Ma D*. Novel mutations of SLC26A4 in Chinese patients with nonsyndromic hearing loss. Acta Otolaryngol. 2013;133(8):833-41

Pan J,Ma D, Sun F, Liang W, Liu R, Shen W, Wang H, Ji Y,Hu R, Liu R, Luo X, Shi H. Over-expression of TFPI-2 promotes atherosclerotic plaque stability by inhibiting MMPs in apoE-/- mice.Int J Cardiol. 2013 Apr 19. [Epub ahead of print]

Xu C, Wang H, He H, Zheng F, Chen Y, Zhang J, Lin X, Ma D*, Zhang H*. Low expression of TFPI-2 associated with poor survival outcome in patients with breast cancer. BMC Cancer. 2013;13(1):118.  

Yao G, Li S, Chen D, Wang H, Zhang J, Feng Z, Guo L, Yang Z, Yang S, Sun C, Zhang X, Ma D*. Compound heterozygous mutations of SLC26A4 in 4 Chinese families with enlarged vestibular aqueduct. Int J Pediatr Otorhinolaryngol. 2013;77(4):544-9  

Xie K, Jin B, Li Y, Luo X, Zhu J, Ma D*, Shi H*.Modulating Autophagy Improves Cardiac Function in a Rat Model of Early-Stage Dilated Cardiomyopathy. Cardiology. 2013;125(1):60-68  

Sang Q, Yan X, Wang H, Feng R, Fei X,Ma D, Xing Q, Li Q, Zhao X,Jin L, He L, Li H, Wang L. Identification and Functional Study of a New Missense Mutation in the Motor Head Domain of Myosin VIIA in a Family with Autosomal Dominant Hearing Impairment (DFNA11). PLoS One. 2013;8(1):e55178  

Li J, Cao Y, Ma XJ, Wang HJ, Zhang J, Luo X, Chen W, Wu Y, Meng Y, Zhang J, Yuan Y, Ma D*, Huang GY*. Roles of miR-1-1 and miR-181c in ventricular septal defects. Int J Cardiol. 2013 Jan 23  

Wu D, hen Y, Xu C, Wang K, Wang H, Zheng F, Ma D*, Wang G*. Characteristic face: a key indicator for direct diagnosis of 22q11.2 deletions in chinese velocardiofacial syndrome patients. PLoS One. 2013;8(1):e54404  

Li CL, Hao SJ, Wang HJ, Jin L, Qing FH, Zheng FY, Zhang P, Chen L, Ma D*, Zhang TY*. MicroRNA expression profiling and target genes study in congenital microtia. Int J Pediatr Otorhinolaryngol. 2013;77(4):483-7  

Fang Y, Fu D, Tang W, Cai Y, Ma D, Wang H, Xue R, Liu T, Huang X, Dong L, Wu H, Shen X. Ubiquitin C-terminal Hydrolase 37, a novel predictor for hepatocellular carcinoma recurrence, promotes cell migration and invasion via interacting and deubiquitinating PRP19. Biochim Biophys Acta. 2013;1833(3):559-72

Sheng W, Wang HJ, Zhang P, Qian YY, Wu Y, Ma XJ, Zheng FY, Chen L, Huang GY*, Ma D*. LINE-1Methylation Status and Its Association with Tetralogy of Fallot in Chinese Infants. BMC Medical Genomic, 2012;5(1):20

Chen YT, Zhang J, Wang HJ, Xu C, Du YY, Luo X, Zheng FY, Zhao JY, Zhang HW, Ma D*. miRNA-135a promotes migration and invasion of breast cancer by targeting HOXA10. BMC Cancer. 2012;12(1):111  

 Luo X, Zhang J, Wang HJ, Du YY, Yang L, Zheng FY, Ma D*. A novel universal TaqMan probe method for detecting microRNAs. Biotechnology Letter, 2012;34(4):627-33  

Yang L, Wang H, Luo X, Mao P, Tian W, Shi Y, Huang G, Zhang J, Ma D*. Virion protein 16 induces demethylation of DNA integrated within chromatin in a novel mammalian cell model. Acta Biochim Biophys Sin. 2012;44(2):154-61  

Xu C, Deng F, Mao Z^, Zhang J, Wang H, Wang J, Mu J, Deng S, Ma D*. The interaction of the second Kunitz-type domain (KD2) of TFPI-2 with a novel interaction partner, prosaposin, mediates the inhibition of the invasion and migration of human fibrosarcoma cells. Biochemical Journal，2012;441(2):665-74.  

Fang Y, Mu J, Ma Y, Ma D, Fu D, Shen X. The interaction between ubiquitin C-terminal hydrolase 37 and glucose-regulated protein 78 in hepatocellular carcinoma.Mol Cell Biochem. 2012;359(1-2):59-66.

Ryu HS, Park SY, Ma D, Zhang J, Lee W. The Induction of MicroRNA Targeting IRS-1 Is Involved in the Development of Insulin Resistance under Conditions of Mitochondrial Dysfunction in Hepatocytes. PLoS One.2011;6(3):e17343.  

Zhao BL, Luo XP, Shi HM, Ma D*. Tissue factor pathway inhibitor-2 is downregulated by ox-LDL and inhibits ox-LDL induced vascular smooth muscle cells proliferation and migration. Throm Res. 2011;128(2):179-85.  

Du YY, Zhang J, Wang HJ, Yan XL, Yang YJ, Yang L, Luo X, Chen YT, Duan T, Ma D*. Hypomethylated DSCR4 is a Placenta Derived Epigenetic Marker for Trisomy 21. Prenatal Diagnosis. 2011;31(2):207-14  

Pan JJ, Shi HM, Luo XP*, Ma D*, Li Y, Zhu J, Liang W, Mu JG, Li J. Recombinant TFPI-2 enhances macrophages apoptosis through upregulation of Fas/FasL and decreases foam cells formation. European Journal of Pharmacology, 2011;654(2):135-41.  

Xiong Y, Zhou QJ, Lou, Guo, Hu, Ma D*, Li XT*. Alternations of maternal and cord plasma haemostasis in preeclampsia before and after delivery. Hypertension in Pregnancy. 2011;30(3):347-58.    

Xiong Y, Zhou Q, Jiang F, Zhou S, Lou Y, Guo Q, Liang W, Kong D, Ma D*, Li X*.Changes of plasma and placental tissue factor pathway inhibitor-2 in women with preeclampsia and normal pregnancy.Thromb Res. 2010;125(6):e317-22.  

Zha BB, Liang W, Liu J, Cheng J, Hong XW, Liu J, Li YM*, Ma D*. Mutation analysis in a Chinese family with multiple endocrine neoplasia type 1. Chin Med J  2010;123(5):　569-73